NMRI Applications - Nutrient Network Modeling Resources

NMRI Applications - Nutrient Network Modeling ResourcesA Metabolic Network Modeling Resource (MNR) is a dynamic database that contains information about nutrient transport throughout the body. This information can be used to formulate an a NutrEval study design that will provide a realistic and compelling evidence base for a New Dietary Ingredient (NDI) application. The database contains a variety of information about the metabolism of nutrients within cells and tissues.A common Nutrient Metabolism error is failing to take the concentration of ketone bodies into account. An improper hypothesis could be that, after an NDI application, ketones are transported from the body and enter the blood stream, causing toxicity and introducing another NDI into the body. This may lead to further testing and additional studies should be initiated, ideally with a new NMRI or database containing NDI results from multiple experiments.One of the most overlooked aspects of the Nutrient Network Modeling Resource (NMR) is the possible inclusion of glucose in the system. In order to be accepted as a NMRI for NMRI applications, research that contains the nutritional supplementation of glucose will be required to be registered at Nutrient Network Modeling Resources (NNM). If the studies were registered with the NNM, an independent third party analysis would be performed.As more NMRI databases become available, it is becoming increasingly difficult to select the correct NMRI for NNM research. Each NMRI has an expert panel, which includes several nutritionists, biochemists, and physiologists who are well versed in the field. However, this does not provide any sort of level of impartial review. Nutrient network modeling must incorporate the criteria of the NNM.A Nutrient Network Modeling Resource (NMR) database that fails to adequately incorporate the scientific and clinical concerns of the NNM or its associated NNM panels, particularly with respect to safety, efficacy, and toxicity, will not be accepted for use by the NNM or the NMRI. A team of clinical scientists will be appointed to review all NMRI applications that were submitted to the NNM or its associated panels. At the same time, a team of independent scientists and industry representatives will be appointed to review NMRI applications from other sources that have not been formally reviewed by the NNM or its associated panels.Amino acids, glucose, and other important components of NMRI applications will be excluded from the application if the quality of the source or analysis is not adequate to meet or exceed the NNM standards. Only those sources that have been formally reviewed will be accepted.An example of a well established NMRI is the Nutrition and Cancer Unit (NCU), which has received many positive reviews from scientific journals. The NCU database offers a significant number of NNMDs to scientists and industry members that will be used for NNMD applications. The database contains all scientific resour ces for the NNI, including many of the NMRI panels that have published several recent reviews in high-impact journals in the field of nutrition and cancer.Most of the NNM guidelines are similar to those of the FDA, which is why so many NNMDs submitted applications to the NNM. By incorporating the FDA's nutritional quality guidelines and the NNM standards, Nutrient Network Modeling Resources, as the NNM is also called, will become a major asset to the nutritional sciences and industry.